Effects of cyclopiazonic acid on Ca2+-dependent CI- current in rabbit atrial myocytes
نویسندگان
چکیده
منابع مشابه
Effects of temperature on intracellular Ca2+ in trout atrial myocytes.
Acute temperature change can be cardioplegic to mammals, yet certain ectotherms maintain their cardiac scope over a wide temperature range. To better understand the acute effects of temperature on the ectothermic heart, we investigated the stimulus-induced change in intracellular Ca(2+) concentration ([Ca(2+)](i); cytosolic Ca(2+) transient) in isolated rainbow trout myocytes at 7 degrees C, 14...
متن کاملCharacterization of effects of endothelin-1 on the L-type Ca2+ current in human atrial myocytes.
The effects of endothelin-1 (ET-1) on the L-type Ca2+ current (I(Ca)) were examined in whole cell patch-clamped human atrial myocytes. Depending on the initial current density, ET-1 (10 nM) increased the amplitude of I(Ca) by 99 +/- 7% or decreased it by 33 +/- 2%. The stimulatory effect predominated on current of low density (2.3 +/- 0.2 pA/pF), whereas I(Ca) of higher density (5.8 +/- 0.3 pA/...
متن کاملATP-dependent effects of halothane on SR Ca2+ regulation in permeabilized atrial myocytes.
OBJECTIVE Previous work suggests that modification of sarcoplasmic reticulum (SR) function may contribute to the cardioprotective effect of halothane during ischaemia and reperfusion. The aim of this study was to investigate the effects of halothane on spontaneous Ca(2+) release from the sarcoplasmic reticulum (Ca(2+) sparks and waves). METHODS Rat atrial myocytes were permeabilized with sapo...
متن کاملGenistein elicits biphasic effects on L-type Ca2+ current in feline atrial myocytes.
A perforated patch recording method was used to determine the effects of genistein (Gen), a protein tyrosine kinase (PTK) inhibitor, on basal L-type Ca2+ current ( I Ca,L) in feline atrial myocytes. Gen (50 μM) elicited biphasic changes in I Ca,L: an initial inhibition (-55 ± 4%; phase 1) followed by a secondary stimulation (34 ± 9%; phase 2) of I Ca,L. Withdrawal of Gen elicited a further pote...
متن کاملDynamics of Ca2+-dependent Cl- channel modulation by niflumic acid in rabbit coronary arterial myocytes.
Calcium-activated chloride channels (Cl(Ca)) are crucial regulators of vascular tone by promoting a depolarizing influence on the resting membrane potential of vascular smooth muscle cells. Niflumic acid (NFA), a potent blocker of Cl(Ca) in vascular myocytes, was shown recently to cause inhibition and paradoxical stimulation of sustained calcium-activated chloride currents [I(Cl(Ca))] in rabbit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1997
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)45440-1